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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2395

Title: 1,3,4-Thiadiazoles, Regioslective O-Demthyltion on Dehydroactive cyclization of 1-(3,4,5-Trimethoxybenoyl)-4-substituted Thiosemicarbazides with Sulphuric acid
Authors: Al-Omar, Mohamed A.
Al-Deeb, Omar A.
Al-Khamees, Hamad A.
El-Emam, Ali A.
Keywords: 1,3,4-Thiadiazoles
Selective O-demethylation
Sulphuric Acid
Issue Date: 2004
Publisher: Taylor & Francis
Citation: Phosphorus, Sulfur, and Silicon: 179; 2509–2517
Abstract: Cyclization of 1-(3,4,5-trimethoxybenzoyl)-4-substituted thiosemicarbazides 2a–g with sulphuric acid at ambient temperature afforded the selectively demethylated products 2-(4-hydroxy-3,5-dimethoxyphenyl)- 5-substituted amino-1,3,4-thiadiazoles 4a–g. Meanwhile, dehydrative cyclization of 1-(3,4,5-trimethoxybenzoyl)-4-(benzyl or t-butyl)thiosemicarbazides 2h,i with sulphuric acid yielded 2-(4-hydroxy-3,5-dimethoxyphenyl)- 5-amino-1,3,4-thiadiazole 5. On the other hand, dehydration of 2h,i by heating with phosphorus oxychloride yielded 2-(3,4,5-trimethoxyphenyl)-5-amino-1,3,4-thiadiazole 6.
Description: Corresponding Author: Dr. Mohamed Al-Omar Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University Riyadh, 11451. Phone: +966-1-4677343, Fax No.+966-1-4676220 Email:malomar1@ksu.edu.sa, drmohammed1423@yahoo.co.uk
URI: http://hdl.handle.net/123456789/2395
ISSN: 1042-6507
Appears in Collections:College of Pharmacy

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