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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2430

Title: Studies on the cardiovascular depressant effects of N-ethyl- and N-benzyl-1,2-diphenylethanolamines in the rat elucidation of the mechanisms of action
Authors: Bakheet, Dana M.
El Tahir, K.E.H.
Al-Sayed, M.I.
El-Obeid, H.A.
Al-Rashood, K.A.
Keywords: N-ethyl 1,2-diphenylethanolamine
N-benzyl 1,2-diphenylethanolamine
Ca21 channels
Heart
Blood vessels
Issue Date: 1999
Publisher: Elsevier Science
Citation: General Pharmacology:33(1);17–22
Abstract: The influence and mechanisms of action of N-ethyl- and N-benzyl-1,2 diphenylethanolamines (compounds E and B, respectively) on the arterial blood pressure and the heart rate of the rat together with their effects on CaCl2-induced arrhythmias in the rat were investigated. Both E and B in doses of (1.5–12 μmol/kg IV) decreased the arterial blood pressure and the heart rate in a dose-dependent manner. Studies with various receptor blockers, enzyme inhibitors and CaCl2 revealed that E-induced cardiovascular depressant effects were mainly due to CaCl2 channel blocking action and activation of cyclic guanylyl cyclase or release of NO whereas the cardiovascular effects of B seemed to involve both blockade of Ca2+ channels and activation of parasympathetic ganglia. Both compounds (12–14.5 μmol/kg) completely protected the rat against CaCl2 (60 mg kg−1)-induced tachyarrhythmias. The B compound seemed to be several times more potent than the E compound in its cardiovascular depressant actions. The results suggest the potential usefulness of both compounds in the treatment of hypertension and supraventricular arrhythmias.
Description: Department of Pharmacology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Kingdom of Saudi Arabia Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia Manuscript received June 24, 1998; accepted manuscript October 7, 1998
URI: doi:10.1016/S0306-3623(98)00269-9
http://hdl.handle.net/123456789/2430
ISSN: 0306-3623/99
Appears in Collections:College of Pharmacy

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