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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2444

Title: Substituted quinazolines, part 2. synthesis and in vitro anticancer evaluation of new 2-substituted mercapto-3H-quinazoline analogs
Authors: Khalil, Ashraf A.
Abdel Hamide, Sami G.
Al-Obaid, Abdulrahman M.
El-Subbagh, Hussein I.
Keywords: Synthesis
4-(3H)-Quinazolinone
Antitumor activity
Issue Date: 4-Apr-2002
Publisher: WILEY-VCH Verlag GmbH & Co
Citation: Arch. Pharm. Pharm. Med. Chem.:2; 95–103
Abstract: A new series of 2-substituted mercapto-3H-quinozolines bearing 6-iodo and 2-heteroarylthio functionswas synthesized and screened for their in vitro antitumor activity.Eighteen compounds were identified as active anticancer agents.N[(3-Benzyl- 4-oxo-6-iodo-3H-quinazoline-l)thioacetyl]-N3-ethylthiosemicarbazide (10), Nbenzoyl- N-[2-(3-benzyl-4-oxo-6-iodo-3H-quinozolin-2-yl)thioacetyl]hydrazine (12),and 2-[(3,6-dioxo-pyridazin-4-yl)thio]-3-benzyl-4-oxo-6-iodo-3H-quinazoline (20)proved to be the most active members in this study. They showed MG-MID, GI50values of 12.8, 11.3, and 13.8 μM, respectively.The detailed synthesis and biologicalscreening data are reported.
URI: http://hdl.handle.net/123456789/2444
ISSN: 0365-6233
Appears in Collections:College of Pharmacy

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