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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2503

Title: Neo-nitro-l-arginine methylester ameliorates myocardial toxicity induced by doxorubicin
Authors: Mansour, Mahmoud Ahmed
El-Din, Ayman Gamal
Nagi, Mahmoud N.
Al-Shabanah, Othman A.
Al-Bekairi, Abdullah M.
Keywords: Doxorubicin
Oxidative Stress
Issue Date: Nov-2003
Publisher: KSBMB & Springer-Verlag
Citation: Journal of Biochemistry and Molecular Biology: 36 (6); 593-596
Abstract: The effects of Nω-nitro-L-arginine methylester (L-NAME) and L-arginine on cardiotoxicity that is induced by doxorubicin (Dox) were investigated. A single dose of Dox 15 mg/kg i.p. induced cardiotoxicity, manifested biochemically by a significant elevation of serum creatine phosphokinase (CPK) activity [EC]. Moreover, cardiotoxicity was further confirmed by a significant increase in lipid peroxides, measured as malon-di-aldehyde (MDA) in cardiac tissue homogenates. The administration of L-NAME 4 mg/kg/d p.o. in drinking water 5 days before and 3 days after the Dox injection significantly ameliorated the cardiotoxic effects of Dox, judged by the improvement in both serum CPK activity and lipid peroxides in the cardiac tissue homogenates. On the other hand, the administration of L-arginine 70 mg/kg/d p.o. did not protect the cardiac tissues against the toxicity that was induced by the Dox treatment. The findings of this study suggest that L-NAME can attenuate the cardiac dysfunction that is produced by the Dox treatment via the mechanism(s), which may involve the inhibition of the nitric oxide (NO) formation. L-NAME may, therefore, be a beneficial remedy for cardiotoxicity that is induced by Dox and can then be used to improve the therapeutic index of Dox.
URI: http://bmbreports.org/jbmb/pdf.php?data=MDkwNDE1MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUIzNi02JTVEMDMxMTIxMTIwMV9wNTkzLnBkZg==
ISSN: 1225-8687
Appears in Collections:College of Pharmacy

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