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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2814

Title: Drug-induced pulmonary fibrosis
Authors: Daba, Mohammed H.
El-Tahir, Kamal E.
Al-Arifi, Mohammed N.
Gubara, Othman A.
Keywords: Drug-induced
Pulmonary fibrosis
Issue Date: 2004
Publisher: Medical Services Department Saudi Arabian Armed forces
Citation: Saudi Medical Journal: 25(6); 700-706
Abstract: Pulmonary fibrosis is characterized by the accumulation of excessive connective tissue in the lungs. Its causes include chronic administration of some drugs for example bleomycin, cyclophosphamide, amiodarone, procainamide, penicillamine, gold and nitrofurantoin; exposure to certain environmental factors such as gases, asbestos and silica and bacterial or fungal infections. Some systemic diseases also predispose to the disease for example rheumatoid arthritis and systemic lupus erythematosus. The disease is associated with release of oxygen radicals and some mediators such as tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), PDGF, IGF-I, ET-I and interleukins 1, 4, 8 and 13. The symptoms of the disease include dyspnea, non-productive cough, fever and damage to the lung cells. It is diagnosed with the aid of chest radiography, high resolution computed tomographic scanning and the result of pulmonary function tests. Drug-induced pulmonary fibrosis may involve release of free oxygen radicals and various cytokines for example IL-Ibeta and TNF-alpha via activation of nuclear transcription factor (NF-beta) as in the case of bleomycin and mitomycin or via release of TGF-beta as in case of tamoxifen or via inhibition of macrophages’ and lymphocytes’ phospholipases as in the case of amiodarone with the resultant accumulation of phospholipids and reduction of the immune system.
Description: From the Department of Clinical Pharmacy (Daba, Al-Arifi, Gubara), Department of Pharmacology (El-Tahir), College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
URI: http://hdl.handle.net/123456789/2814
ISSN: 0379-5284
Appears in Collections:College of Pharmacy

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