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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2855

Title: Beneficial effect of nitric oxide synthase inhibitor on hepatotoxicity induced by allyl alcohol
Authors: Alam, Khurshid
Nagi, Mahmoud N.
Al-Shabanah, Othman A.
Al-Bekairi, Abdullah M.
Keywords: Allyl Alcohol
Hepatotoxicity
Aminoguanidine
Nitric Oxide
Mice
Issue Date: 2001
Publisher: John Wiley
Citation: Journal of Biochem Molecular Toxicology: 15 (6); 317-321
Abstract: The effect of aminoguanidine (a selective inhibitor of inducible nitric oxide synthase) on allyl alcohol-induced liver injury was assessed by the measurement of serum ALT and AST activities and histopathological examination. When aminoguanidine (50– 300 mg/kg, i.p.) was administered to mice 30 min before a toxic dose of allyl alcohol (75 mL/kg, i.p.), significant changes related to liver injury were observed. In the presence of aminoguanidine the level of ALT and AST enzymes were significantly decreased. All symptoms of liver necrosis produced by allyl alcohol toxicity almost completely disappeared when animals were pretreated with aminoguanidine at 300 mg/kg. Depletion of hepatic glutathione as a consequence of allyl alcohol metabolism was minimal in mice pretreated with aminoguanidine at 300 mg/kg. It was found that the inhibition of toxicity was not due to alteration in allyl alcohol metabolism since aminoguanidine did not effect alcohol dehydrogenase activity both in vivo and in vitro.
Description: Department of Pharmacology, College of Pharmacy, King Saud University
URI: http://hdl.handle.net/123456789/2855
ISSN: 1095-6670
Appears in Collections:King Saud University Initial Collection

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