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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2893

Title: Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice
Authors: Gamal el-din, Ayman M.
Mostafa, Adel M.
Al-Shabanah, Othman A.
Al-Bekairi, Abdullah M.
Nagi, Mahmoud N.
Keywords: Acetaminophen
Arabic gum
Nitric oxide
Issue Date: 30-Jun-2003
Publisher: Elsevier science
Citation: Pharmacological Research: 48; 631–635
Abstract: Overdose of acetaminophen, a widely used analgesic drug, can result in severe hepatotoxicity and is often fatal. This study was under-taken to examine the effects of arabic gum (AG), which is commonly used in processed foods, on acetaminophen-induced hepatotoxicity inmice. Mice were given arabic gum orally (100 g l−1) 5 days before a hepatotoxic dose of acetaminophen (500 mg kg−1) intraperitoneally.Arabic gum administration dramatically reduced acetaminophen-induced hepatotoxicity as evidenced by reduced serum alanine (ALT) andaspartate aminotransferase (AST) activities. Acetaminophen-induced hepatic lipid peroxidation was reduced significantly by arabic gumpretreatment. The protection offered by arabic gum does not appear to be caused by a decrease in the formation of toxic acetaminophenmetabolites, which consumes glutathione, because arabic gum did not alter acetaminophen-induced hepatic glutathione depletion. Ac-etaminophen increased nitric oxide synthesis as measured by serum nitrate plus nitrite at 4 and 6 h after administration and arabic gumpretreatment significantly reduced their formation. In conclusion, arabic gum is effective in protecting mice against acetaminophen-inducedhepatotoxicity. This protection may involve the reduction of oxidative stress.
URI: http://hdl.handle.net/123456789/2893
ISSN: 1043-6618
Appears in Collections:College of Pharmacy

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