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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3140

Title: Pharmacological and safety evaluation studies on lepidium sativum L, seeds
Authors: Al-Yahya, M.A.
Mossa, J.S.
Ageel, A.M.
Rafatullah, S.
Keywords: Lepidium sativum L.
Anti-inflammatory
Antipyretic
Analgesic
Haematological effects
Safety evaluation
Issue Date: 1994
Publisher: Elsevier Science
Citation: Phytomedicine: 1; 155-159
Abstract: An ethanolic extract of Cress (Lepidium sativum L.) seeds has been studied for anti-inflammatory, antipyretic and analgesic activities and to evaluate the safety of their acute and chronic use in rodents. The extract significantly inhibited carrageenan-induced paw edema and reduced the yeast-induced hyperpyrexia. It also prolonged the reaction time of mice on the hot plate. However, the extract exacerbated indomethacin-induced gastric mucosal damage. The coagulation studies showed a significant increase in fibrinogen level and an insignificant decrease in prothrombin time, confirming its coagulating property. The toxicity tests showed that the administration of extract in single doses of 0.5 to 3.0g/kg did not produce any adverse effects or mortality in mice, whereas the animals treated with extract (100 mg/kg/day) for a period of 3 months in drinking water showed no symptoms of toxicity except a statistically insignificant higher mortality rate. These findings suggest that the seeds of Cress (L. sativum) possess significant anti-inflammatory, antipyretic, analgesic and coagulant activities, and are free from serious side or toxic effects.
URI: http://www.elsevier.com/wps/find/journaldescription.cws_home/701794/description#description
http://hdl.handle.net/123456789/3140
ISSN: 0944-7113
Appears in Collections:College of Pharmacy

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