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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3317

Title: Antigastric Ulcer studies on 'saffron' crocus sativus L. in Rats
Authors: Al-Mofleh, L.A.
Alhaider, A.A.
Mossa, J.S.
Al-Sohaibani, M.O.
Qureshi, S.
Rafatullah, S.
Keywords: Saffron
Crocus sativus
Arabian coffee
Gastric antiulcer
Issue Date: 2006
Publisher: Asian Network for Scientific Information
Citation: Pakistan Journal of Biological Sciences: 9(6); 1009-1013
Abstract: Saffron, Crocus sativus Linn. (Family Iridaceae) commonly known as Zaa'fran is used as a flavoring agent and an important ingredient of Arabic coffee (Gahwa). It is also used in many gastric ailments. An aqueous suspension of saffron was subjected for evaluating gastric antiulcer activity induced by pylorus ligation (Shay rats), indomethacin and various necrotizing agents including (80% ethanol, 0.2 M NaOH and 25% NaCl) in rats. Gastric wall mucus and non-protein sulfhydryl contents were also estimated in rats. Histopathological assessment of rat stomach was carried out. The saffron aqueous suspension at doses (250 and 500 mg kg- 1 ) exhibited decrease in basal gastric secretion and ulcer index in Shay rats and indomethacin treated groups. Gastric wall mucus elevation was observed. No significant histopathological changes were noted. A large margin of safety was observed in animals after acute and chronic treatment.) Saffron exhibited significant antisecretory and antiulcer activities without causing any deleterious effects on acute and chronic toxicity in rodents.
URI: http://hdl.handle.net/123456789/3317
ISSN: 1028-8880
Appears in Collections:College of Pharmacy

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