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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3329

Title: Protective effect of swertia chirata against indomethacin and other ulcerogenic agent-induced gastric ulcers
Authors: Rafatullah, S.
Tariq, M.
Mossa, J.S.
Al-Yahya, M.A.
Al-Said, M.S.
Ageel, A.M.
Keywords: Protection
Issue Date: 1993
Publisher: Bioscience Ediprint Inc.
Citation: Drugs under Experimental and Clinical Research: 19 (2); 69-73
Abstract: The effect of Swertia chirata has been studied on experimentally induced gastric ulcers in rats. The ethanolic extract of chirata significantly reduced the intensity of gastric mucosal damage induced by indomethacin and necrotizing agents. It produced a significant decrease in gastric secretion •in pylorus-ligated rats. The extract inhibited acetylcholine-induced contraction of guinea pig ileum, suggesting its anti-cholinergic activity. Pretreatment of rats with the extract significantly prevented ethanol-induced gastric wall mucus depletion and restored the non-protein sulfhydryl (NP-SH) content in the glandular stomachs. These findings support the use of chirata for the treatment of gastric ulcers in traditional medicine.
URI: http://hdl.handle.net/123456789/3329
ISSN: 0378-6501
Appears in Collections:College of Pharmacy

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