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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3428

Title: Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh
Authors: Alsaghir, Abdullah H.
Al-Mobeireek, Abdullah F.
Al-Jahdali, Hamdan
Al-Eithan, Abdulsalam
Al-Otair, Hadil
Al-Dayel, Fouad
Keywords: Pneumonia
Issue Date: Jan-2007
Publisher: King Faisal specialist hospital and research centre
Citation: Annals of Saudi Medicine 27(1):32-35
Abstract: BACKGROUND: Because reports of bronchiolitis obliterans organizing pneumonia (BOOP) are lacking from the Middle East, we conducted a retrospective review of of all histopathologically proven cases of BOOP over a 10-year period at three tertiary care hospitals in Riyadh and describe the clinical features and outcome. METHODS: Charts at the three hospitals were searched using a specific code for BOOP or cryptogenic organizing pneumonia (COP). Lung specimens had to show histological proof of BOOP with a compatible clinical picture. Chest radiographs and high-resolution CT scans were reviewed. RESULTS: Twenty cases of biopsy-proven BOOP had well-documented clinical and radiographic data. There were 11 males and 9 females (mean age, 58 years; range, 42-78). The clinical presentation of BOOP was acute or subacute pneumonia-like illness with cough (85%), fever (70%) dyspnea, (85%) and crackles (80%). The most frequent radiological pattern was a bilateral alveolar infiltrate. The most common abnormality on pulmonary function testing (n=14) was a restrictive pattern (11 patients). Most patients (70%) had no underlying cause (idiopathic BOOP). Other associations included thyroid cancer, rheumatoid arthritis, syphilis and Wegner's granulomatosis. Ten patients (50%) had a complete response to steroids, 6 (30%) had a partial response and 3 (15.8%) with secondary BOOP had rapid progressive respiratory failure and died. CONCLUSION: The clinical presentation of BOOP in our patients is similar to other reported series. A favorable outcome occurs in the majority of cases. However, BOOP may occasionally be associated with a poor prognosis, particularly when associated with an underlying disease.
URI: http://saudiannals.net/pdfs/06-277.pdf
Appears in Collections:College of Medicine

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