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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3603

Title: Isoniazid acetylation phenotyping in Saudi Arabs
Authors: Matar, K.M.
Mayetj, A.Y.
Ayoola, E.A.
Bawazir, S.A.
Al-FalehJ, F.Z.
Al-WazzanJ, A.
Keywords: Acetylator
Phenotype
Isoniazid
Saudi Arabs
Issue Date: 2004
Publisher: Blackwell Publishing
Citation: Journal of Clinical Pharmacy and Therapeutics: 29, 443-447
Abstract: Aims: The present study is designed to investigate the acetylator status in Saudi Arabs. Methods: Isoniazid (INH) acetylation phenotyping was studied in 136 Saudi Arabs in Riyadh, Saudi Arabia, using a single plasma sample taken 3 h post-INH oral dose of 200 mg. Metabolic ratio (MR) of plasma acetyl-INH (Ac-INH) to INH was used to determine the acetylation phenotype. Results: The MR had a bimodal distribution with an antimode of 1-0. The frequency distribution of slow acetylators (MR < 1-0) was 94-9% (n = 129). Using Hardy-Weinberg Law, the gene frequency {a) of the recessive allele determining slow acetylator phenotype was found to be 0*97. Conclusion: INH phenotyping suggests a high frequency of slow acetylators among Saudi Arabs. There was no association between the MR of plasma Ac-INH/INH and age or gender.
URI: http://hdl.handle.net/123456789/3603
ISSN: 0269-4727
Appears in Collections:College of Pharmacy

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