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|Title: ||Tissue factor pathway inhibitor, natural coagulation inhibitors and hemostatic activation markets in patients with acute coronary syndromes|
|Authors: ||Al-Nozha, Mansour M.|
Abdel-Gader, Abdel-Galil M.
Arafah, Mohammed R.
Al-Maatouq, Mohammed A.
Al-Shahid, Maie S.
Al-Harthi, Saad S.
Khan, Nazeer B.
Abdullah, Moheeb A.
|Keywords: ||Tissue factor|
|Issue Date: ||2005 |
|Publisher: ||Medical Services Department, Saudi Arabian Armed Forces, Ministry Of Defence And Aviation|
|Citation: ||Saudi Medical Journal: 26 (6): 937-942|
|Abstract: ||This study aims at characterizing the
hemostatic changes, in a large cohort of Saudi Arab
patients with acute coronary syndromes.
Methods: We consecutively enrolled 389 patients
(unstable angina [UA]: n=181; myocardial infarction
[MI]: n=208) in this study at King Khalid University
Hospital, Riyadh, Kingdom of Saudi Arabia in the period
from April 2000 to November 2001. We collected blood
samples before coronary angiography. Controls (n=101)
were healthy males and females. All hemostatic assays
were undertaken using enzyme linked immunosorbent
assay based techniques and commercial kits.
Results: The mean plasma levels of both bound and
free tissue factor pathway inhibitors (TFPI) were
significantly higher and to comparable levels, in patients
with MI and UA, than in healthy control levels. Markers
of thrombin generation: the mean levels of prothrombin
fraction 1+2, thrombin antithrombin complexes, and
D-Dimer were very significantly elevated in the 2
patients groups than in controls. Proteins C and
antithrombin III showed statistically significant reduction
especially in patients with MI. Plasminogen activator
inhibitor levels were significantly elevated in the 2
patient groups, but were higher in MI patients. The mean
levels of fibrinogen and D-Dimer as well thrombin
antithrombin complex were higher and the levels of free
tissue factor pathway inhibitor were lower in patients
with 3-vessel coronary artery disease than those with
single and double vessel disease.
Conclusion: The results of this study confirm the
existence, and to a similar extent, of a hypercoagulable state in Saudi patients with MI than UA and in those with 3-vessel coronary artery disease than those with one or 2-vessel disease.|
|Description: ||Departments of Cardiology (Al-Nozha, Arafah, Al-Harthi), Physiology (Abdel-Gader), Endocrinology (Al-Maatouq), College of Medicine,
King Khalid University Hospital|
|Appears in Collections:||College of Medicine|
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