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|Title: ||Protective hepatitis b antibodies (anti-HBs) after three doses of hepatitis b vaccine in a cohort of children in Riyadh, Saudi Arabia|
|Authors: ||Al-Zamil, Fahad|
Al-llamidi, Abriulaj A.
Al-Hcrnish, Abdullah S.
Abdullah, Asaad M.
Al-Habib, Sulaiman A.
|Keywords: ||Hepatitis B|
|Issue Date: ||2001 |
|Citation: ||Curr Pedtr Res: 5 (1);|
|Abstract: ||The hepatitis B vaccine was added as the seventh primary immuiiugen of the Expanded
Program on Immunisation (EPIj in October 1989 in the Kingdom or Saudi Arabia hut the
schedule was not altered. It consists uf active varcinalion at birth, six weeks and (lien six
months of aye without hepatitis B surface antigen (HBsAg) screening.
The objective of this siudv was to determine the scrnpositivity rate or antibody to hepa(ili>
B surface antigen (anti-HBs) after three doses of hepatitis B vaccine in children who came
for pediatric check up service at Sulaimun Al-Habih Medical Center in Riyadh. Saudi
A retrospective chart review was conducted for all the children starring from January
I u97 at the private medical center in Riyadh, Saudi Arabia. Anfl-HBs titre equal to or
higher than 10 inlU.'mL is considered positive. *
'One thousand and ei^ht patients satisfied our rriteria and were included in the study.
Their age ranged hetwecn 0-75 - IK years (mean 7.1 +• 3.7 years). Five hundred and nmclytwo
(58.7%) were males and 416 (41.3%) were females. Overall seropositiviiv rate was
H.3.1 % with the higher rate in those younger than seven years of age (X6.7%) and lower rate
in (hose older than seven years (7g.7%). The mean age of the seropositive gruup WflS
significantly less than that uf the seronegative group (I' < 0.01) Thrre was no difference
helween Ihe rate of seroposilivity hetween males and females.
We conclude that the overall seropositivlty rale in Saudi Arabia is 83%, The rate in
infants following universal infant hepatitis B vaccination is acceptable. Further studies are
needed in older children and adolescents.|
|Appears in Collections:||College of Medicine|
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