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http://hdl.handle.net/123456789/3734
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| Title: | Azithromycin and erythromycin ameliorate the extent of colonic damage induced by acetic acid in rats |
| Authors: | Mahgoub, Afaf
El-Medany, Azza
Mustafa, Ali
Arafah, Maha
Moursi, Mahmoud |
| Keywords: | Ulcerative
Colitis
IBD
Inflammatory
Perpetuation
Etiology |
| Issue Date: | 2005 |
| Publisher: | Elsevier |
| Citation: | Toxicology and Applied Pharmacology: 205; 43-52 |
| Abstract: | Ulcerative colitis is a common inflammatory bowzl disease (IBD) of unknown etiology. Recent Studies have revealed the rule of some microorganisms in the initiation and perpetuation of IBD. The role of antibiotics in the possible modulation or colon inflammations still uncertain. In the study, we evaluated the effects of two macrolides namely azithromycin and erythromycin at different doses on the exteddnt and severity of ulcerative colitis caused by administration of 3% acetic acid in rats. The lesiors and the inflammatory response were assessed by histrology and measurement of mycloperoxides (MPO) activity |
| Description: | Department of Pharmacology, College of Medicine, King Saud University, Riyadh |
| URI: | http://hdl.handle.net/123456789/3734 |
| ISSN: | 0041-008X |
| Appears in Collections: | College of Medicine
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