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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4107

Title: Malaria with special stress on plasmodium falciparum resistance to chloroquine and its reversal
Authors: El Tahir, Karnal E H.
Al-Shabanah, Othman A.
Keywords: Malaria
Plasmodium falciparum
Drug Resistance
Treatment
Chloroquine
Reversal of resistance
Issue Date: 2001
Publisher: Saudi Pharmaceutical Society
Citation: Saudi Pharmaceutical Journal: 9 (3-4); 136-151
Abstract: This review outlines the life cycle of the malarial parasites, details out the intra-erythrocytic activities of the Plasmodia with regard to the sources of the various nutrients required by them such as the amino acids, glucose, pyrimidine. purines, fatty acids and folic acid. It also discusses the various ways available to combat malaria with an emphasis on chemotherapy and vaccination, The review also discusses resistance of the various Plasmodia to the available anti-malarial* and concentrated on the various ways through which the malarial parasite Plasmodium falitparurm acquires: resistance to chloroquine and pinpointed the various ways for the reversal of the resistance chemically. These included reduction of the vacuolar pH of the parasite, suppression of chloroquine efflux via inhibition of the membrane-bound p-glycoprotein pump, activation of the proton pumping ATPase system, enhancement of chloroquine binding to the chemically altered FPIX and the enhancement of chloroquine binding to die vacuolar lysosomal enzymes.
Description: Department of Pharmacology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
URI: http://wwww.ksu.edu.sa/colleges/pharm/spj.htm
http://hdl.handle.net/123456789/4107
ISSN: 1319-0164
Appears in Collections:Saudi Pharmaceutical Society

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