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| Title: | Effect of alpinia galanga treatment on cytological and biochemical changes induced by cyclophosphamide in mice |
| Authors: | Qureshi, S.
Shah, A.H.
Ahmed, M.M.
Rafatullah, S.
Bibi, F.
Al-bekairi, A.M. |
| Keywords: | Effect
Alpinia
Cytological
Biochemical
Induced
Cyclophosphamide
Mice
Treatment
Galanga
CP-treatment |
| Issue Date: | 1994 |
| Publisher: | Swets & Zeitlinger |
| Citation: | Int. J. Pharmacog: 32 (2); 171-177 |
| Abstract: | An ethanol extract of Alpinia galanga was administered to mice. This treatment did not affect the
number of micronucleated polychromatic erythrocytes (PCE) in bone marrow cells, alter the protein
and nucleic acid contents in liver and testes, or cause mitodepression of bone marrow. Cyclophosphamide
(CP) induced micronucleated PCE, and A. galanga treatment significantly reduced this
effect without altering cytotoxicity. The minimum effective dose of A. galanga extract required to
produce this effect was 125 mg/kg body weight. Biochemical changes caused by CP-treatment in the
liver of treated animals were also significantly inhibited by A. galanga treatment. |
| URI: | http://hdl.handle.net/123456789/4214 |
| ISSN: | 0925-1618 |
| Appears in Collections: | College of Pharmacy
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