DSpace

King Saud University Repository >
King Saud University >
COLLEGES >
Health Colleges >
College of Pharmacy >
College of Pharmacy >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4280

Title: In vitro release of disopyramide from cellulose acetate butyrate microspheres
Authors: Radwan, Mahasen A.
Price, James C.
Tackett, Randall .L.
Keywords: Vitro
Disopyramide
Cellulose
Acetate
Butyrate
Microspheres
Medical Sciences
Issue Date: 1995
Publisher: Marcel Dekker, Inc
Citation: Drug Development and Industrial Pharmacy: 21 (12); 1453-1462
Abstract: Disopyramide was microencapsulated with cellulose acetate butyrate (CAB) using an emulsion-solvent evaporation process. Drug dissolution from microcapsules was studied in both simulated gastric (SGF) and intestinal fluids (SIF) under sink conditions using the USP paddle method. There was no significant difference between drug release into SIF and SGF. As the CAB to drag ratio decreased from 3:1 to 2:1 at constant polymer mass, the drug release rate increased and the T5q% decreased from 2.3 hr to 0.3 hr for 303 fim particles. Dissolution T$o% increased from 0.4 hr to 2 hr when the mean microcapsule size was increased from 153 to 428 [im (26% drug loading). The addition of acetone to the external phase during preparation shifted the size distribution toward larger particles, but resulted in a higher drug dissolution rate for a given particle size range. A shift to smaller particles was obtained upon increasing the concentration of surfactant. The dissolution profiles were described by the Higuchi and Baker-Lonsdale equations for drug release from spherical matrices up to 90% of the drug release.
Description: Department of Pharmaceutics and Cardiovascular Pharmacodynamics Laboratory, College of Pharmacy, University of Georgia, Athens, GA *King Saud University, College of Pharmacy, Riyadh, Saudi Arabia.
URI: http://hdl.handle.net/123456789/4280
Appears in Collections:College of Pharmacy

Files in This Item:

File Description SizeFormat
In vitro release of disopyramide from cellulose acetate butyrate microspheres.pdf447.41 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - Feedback