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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4453

Title: NAN- 190, a possible specific antagonist for methamphetamine
Authors: Ginawi, Q.T.
Al-Majed, A.A.
Al-Suwailem, A.K.
Keywords: Methamphetamine
NAN-190
Locomotor Activity
Anorexia
Hyperthermia
Antinociception
Serotonin (5-HT)
تاريخ النشر: 2005
Publisher: Elsevier
Citation: Regulatory Toxicology and Pharmacology :(41); 122—127
Abstract: Effect of NAN-190, a selective 5-HTIA receptor antagonist, on methamphetamine-induced locomotor activity, anorexia, analgesia, and hyperthermia was investigated in male mice. Methamphetamine (1.5mg/kg, i.p) produced a significant increase in locomotor activity, which was significantly antagonized by NAN-190 at a dose of 4 mg/kg, i.p. NAN-l90 did not alter the antinociceptive activity of mice when it was administered alone. Methamphetamine (2mg/kg, i.p) produced a significant decrease in food intake of mice, which were deprived of food during the previous 24 h. This anorectic activity of methamphetamine was significantly antagonized by NAN-190 at a dose of 2mg/kg, i.p. NAN-190 did not alter the food intake of mice when it was administered alone. Methamphetamine (2 mg/kg, i.p) also produced a significant increase in body temperature of mice, which was significantly antagonized by NAN- 190 at a dose of 0.5 mg/kg, i.p. NAN-l90 did not alter the body temperature of mice when it was administered alone. In the writhing test, methamphetamine (1 mg/kg, i.p) produced a significant antinociceptive effect in mice. This was significantly antagonized by NAN-190 at a dose of 1 mg/kg, i.p. NAN-190 did not alter the antinociceptive activity of mice when it was administered alone. The results of the present study indicate a possible role for serotonergic mechanisms, in addition to the catecholaminergic systems, in the above-studied activities of methamphetamine in mice. This role is possibly mediated through direct stimulation of the 5-HTIA receptor subtype. All of the above-studied activities of methamphetamine were antagonized by NAN-190, which may indicate that NAN-190 is a possible antagonist for methamphetamine.
URI: http://hdl.handle.net/123456789/4453
يظهر في المجموعات:College of Pharmacy

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