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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4487

Title: Synthesis of some new quinazoline analogs and their antimicrobial activity
Authors: El-Azab, Adel S.
Kadi, Adnan A.
Alafeefy, Ahmed M.
Abdel-Hamide, S.G.
Keywords: Synthesis
2-mercaptoquinazoline
Quinazoline-2
4-dithione
2-aminoquinazoline
Benzimidazole
Pyridazine
Antimicrobial screening
Issue Date: 2009
Publisher: King Saud University
Abstract: Two new series of 6-iodo-2,4-dithio-4(3H)quinazoline (2-9) and 6-iodo-2-thio-4-oxo-quinazoline (10-21) were prepared and screened for their antimicrobial activity. Compounds 10, 19 and 20, showed marked broad spectrum antimicrobial activity against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungi. It seems that the connected heterocyclic rings such as benzimidazole and pyridazine, has improved the antimicrobial activities. The detailed synthesis and the antimicrobial screening of the new compounds are reported.
Description: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
URI: http://hdl.handle.net/123456789/4487
Appears in Collections:King Saud University Initial Collection

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