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|Title: ||Synthesis of some new quinazoline analogs and their antimicrobial activity|
|Authors: ||El-Azab, Adel S.|
Kadi, Adnan A.
Alafeefy, Ahmed M.
|Issue Date: ||2009 |
|Publisher: ||King Saud University|
|Abstract: ||Two new series of 6-iodo-2,4-dithio-4(3H)quinazoline (2-9) and 6-iodo-2-thio-4-oxo-quinazoline (10-21) were prepared and screened for their antimicrobial activity. Compounds 10, 19 and 20, showed
marked broad spectrum antimicrobial activity against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungi. It seems that the connected heterocyclic rings such as benzimidazole
and pyridazine, has improved the antimicrobial activities. The detailed synthesis and the antimicrobial screening of the new compounds are reported.|
|Description: ||Department of Pharmaceutical Chemistry, College of Pharmacy,
King Saud University, P.O. Box 2457, Riyadh 11451,
|Appears in Collections:||King Saud University Initial Collection|
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