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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4547

Title: Effect of commiphora molmol (Oleo-gum-resin) on the cytological and biochemical changes induced by cyclophosphamide in mice
Authors: Al-Harbi, M.M.
Qureshi, S.
Ahmed, M.M.
Shah, A.H.
Rafatullah, S.
Keywords: Commiphora Molmol
Biochemical Changes
Issue Date: 1994
Publisher: Institute for Advanced Research in Asian Science and Medicine
Citation: American Journal of Chinese Medicine: 22 (1); 77-82
Abstract: The anticlastogenic and biochemical potentials of Commiphora molmol were studied in Swiss albino mice treated with cyclophosphamide (CP). The C. molmol treatment (125-500 mg/kg) showed no mutagenicity. It caused a highly significant and dose-dependent mitodepressant effect in the femoral cells and reduction of RNA levels in hepatic cells as compared with the control. CP treatment showed significant increase in the frequency of micronuclei, cytotoxicity and reduction in the contents of nucleic acids and proteins. Pretreatment with C. molmol could neither alter the biochemical and cytological effects of CP nor show any additive effect of both treatments.
URI: http://hdl.handle.net/123456789/4547
Appears in Collections:College of Pharmacy

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