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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4740

Title: Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice
Authors: Mansour, Mahmoud A.
Keywords: Thymoquinone
Carbon tetrachloride
Issue Date: 2000
Publisher: Elsevier
Citation: Life Sciences: 66 (26); 2583-2591
Abstract: The effects of thymoquinone (TQ) and desferrioxamine (DFO) against carbon tetrachloride (CCU)-induced hepatotoxicity were investigated. A single dose of CCU (20 ul/kg, i.p.) induced hepatotoxicity, manifested biochemically by significant elevation of activities of serum enzymes, such as alanine transaminase (ALT, EC: ) , aspartate transaminase (AST, EC: ) and lactate dehydrogenase (LDH, EC: Hepatotoxicity was further evidenced by significant decrease of total sulfhydryl (-SH) content, and catalase (EC: activity in hepatic tissues and significant increase in hepatic lipid peroxidation measured as malondialdhyde (MDA). Pretreatment of mice with DFO (200 mg/kg i.p.) 1 h before CCU injection or administration of TQ (16 mg/kg/day, p.o.) in drinking water, starting 5 days before CCU injection and continuing during the experimental period, ameliorated the hepatotoxicity induced by CCI4, as evidenced by a significant reduction in the elevated levels of serum enzymes as well as a significant decrease in the hepatic MDA content and a significant increase in the total sulfhydryl content 24 h after CCU administration. In a separate in vitro assay, TQ and DFO inhibited the non-enzymatic lipid peroxidation of normal mice liver homogenate induced by Fe3 +/ascorbate in a dose-dependent manner. These results indicate that TQ and DFO are efficient cytoprotective agents against CCU-induced hepotoxicity, possibly through inhibition of the production of oxygen free radicals that cause lipid peroxidation.
URI: http://hdl.handle.net/123456789/4740
Appears in Collections:College of Pharmacy

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