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|Title: ||Synthesis and biological screening of some new substituted 2-Mercapto-4-(3H)-Quinazolinone analogs as anticonvulsant agents|
|Authors: ||Kadi, Adnan A.|
El-Azab, Adel S.
Alafeefy, Ahmed M.
|Issue Date: ||2009 |
|Publisher: ||King Saud University|
|Citation: ||Arizona Journal of Pharmaceutical Science:34;147-167|
|Abstract: ||A new series of 2-mercapto-3-(4-chlorophenyl)-4-oxo-6-iodoquinazoline
was synthesized and characterized by their elemental analysis, 1H NMR and mass spectral data. The anticonvulsant activities of prepared compounds have been examined using the PTZ-seizure threshold test. Compounds 2a,b, 3a, 4a,b, 12 and 13a-c showed a significant anticonvulsant activity (at 200 mg/kg dose/level).|
|Appears in Collections:||King Saud University Initial Collection|
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