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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4885

Title: Synthesis and biological screening of some new substituted 2-Mercapto-4-(3H)-Quinazolinone analogs as anticonvulsant agents
Authors: Kadi, Adnan A.
El-Azab, Adel S.
Alafeefy, Ahmed M.
Abdel-Hamide, S.G.
Keywords: Chlorophenyl
Iodoquinazoline
Anticonvulsant
Compounds
Issue Date: 2009
Publisher: King Saud University
Citation: Arizona Journal of Pharmaceutical Science: 34; 135-155
Abstract: A new series of 2-mercapto-3-(4-chlorophenyl)-4-oxo-6-iodoquinazoline was synthesized and characterized by their elemental analysis, 1H NMR and mass spectral data. The anticonvulsant activities of prepared compounds have been examined using the PTZ-seizure threshold test. Compounds 2a,b, 3a, 4a,b, 12 and 13a-c showed a significant anticonvulsant activity (at 200 mg/kg dose/level).
Description: Corresponding Author: Dr. Adnan A. Kadi Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia. Phone: +966-1-467-7344 Fax: +966-1-467-6220 Email: akadi@ksu.edu.sa
URI: http://hdl.handle.net/123456789/4885
Appears in Collections:College of Pharmacy

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