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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5076

Title: Evaluation of turmeric (curcuma longa) for gastric and duodenal antiulcer activity in rats
Authors: Rafatullah, S.
Tariq, M.
Al-Yahya, M.A.
Mossa, J.S.
Ageel, A.M.
Keywords: Evaluation
Curcuma Longa
Duodenal Antiulcer
Issue Date: 1990
Publisher: Elesiever
Citation: Journal of Ethnopharmacology: 29; 25- 34
Abstract: An ethanol extract of turmeric was studied in rats for its ability to inhibit gastric secretion and to protect gastroduodenal mucosa against the injuries caused by pyloric ligation, hypothermic-restraint stress, indomethacin, reserpine and cysteamine administration and cystodestructive agents including 80% ethanol, 0.6 M HC1, 0.2 M NaOH and 25% NaCl. An oral dose of 500 mg/kg of the extract produced significant anti-ulcerogenic activity in rats subjected to hypothermic-restraint stress, pyloruic ligation and indomethacin and reserpine administration. The extract had a highly significant protective effect against cystodestructive agents. The reduction in the intensity of ulceration of cysteamine-induced duodenal ulcers was not found to be statistically significant. Turmeric extract not only increased the gastric wall mucus significantly but also restored the non-protein sulfhydryl (NP-SH) content in the glandular stomachs of the rats.
URI: http://hdl.handle.net/123456789/5076
ISSN: 0378-8741
Appears in Collections:College of Pharmacy

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