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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5116

Title: Gastric antisecretory, antiulcer and cytoprotective properties of Ethanolic extract of Alpinia Galanga willd in rats
Authors: Al-Yahya, M.A.
Rafatullah, S.
Mossa, J.S.
Ageel, A.M.
Al-Said, M.S.
Keywords: Alpinia galanga
Gastric secretion
Gastric ulcers
Gastric wall mucus
Issue Date: 1990
Publisher: John Wiley & Sons
Citation: Phytotherapy Research: 4 (3); 112-114
Abstract: The effect of Alpinia galanga extract has been studied on experimentally induced gastric ulcers in rats. The ethanolic extract of A. galanga at a dose of 500mg/kg, significantly reduced the intensity of gastric mucosal damage induced by pyloric ligation and hypothermic restraint stress in rats. It produced a significant decrease in gastric secretion in pylorus ligated rats and a highly significant cytoprotective effect against 80% ethanol-, 0.6 M HC1-, 0.2 M NaOH- and 25% NaCl-induced cytodestruction. Pretreatment with the extract significantly prevented hypothermic stress-induced gastric wall mucus depletion. These findings suggest that a significant antisecretory and cytoprotective action of A. galanga may be responsible for its antiulcer activity.
Description: Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh-11451, Saudi Arabia Phone: +96614677262 Fax: +96614677245 Email: alyahya@ksu.edu.sa
URI: http://hdl.handle.net/123456789/5116
ISSN: 0951-418X
Appears in Collections:College of Pharmacy

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