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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5223

Title: Gastric and duodenal antiulcer and cytoprotective effects of Aframomum Melegueta in rats
Authors: Rafatullah, S.
Al-Yahya, M.A.
Galal, A.M.
Al-Said, M.S.
Keywords: Aframomum melegueta
Cytoprotection
Gastric
Ulcers
Duodenal ulcers
Traditional medicine
Issue Date: 1995
Publisher: Swets & Zeitlinger
Citation: International Journal of Pharmacognosy: 33 (4); 311-316
Abstract: An ethanol extract of Aframomum melegueta (AMZ) has been studied for its ability to inhibit gastric secretion and to protect gastroduodenal mucosa against the injuries caused by pyloric ligation, hypothermic restraint stress, indomethacin, cysteamine and cytodestructing agents (80% ethanol, 0.6 M HCl, 0.2 M NaOH and 25% NaCl) in rats. The results of this study demonstrate that ethanol extract of AMZ had significant effects on various experimentallyinduced ulcers. It produced a dose-dependent inhibition of basal gastric secretion in pylorus-ligated rats and reduced significantly the intensity of gastric lesions induced by pylorus ligation, hypothermic restraint stress, indomethacin, mucosal damaging agents and duodenal ulcers induced by cysteamine. The concentration of nonproteinsulfhydryls was decreased significantly in gastric mucosa after administration of 80% ethanol. Treatment with AMZ extract replenished the reduced level of gastric mucosal nonprotein sulfhydryls. Acute toxicity tests showed no toxic symptoms and mortality over a period of 14 days with doses of0.25-4g/kg. These findings suggest that AMZ extract exerts antiulcer effects by its antisecretory activity, increasing gastric mucosal resistance and cytoprotective activities.
Description: Medicinal, Aromatic and Poisonous Plants Research Center and Dept. of Pharmacognosy, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh-11451, Kingdom of Saudi Arabia
URI: http://hdl.handle.net/123456789/5223
ISSN: 09251618
Appears in Collections:King Saud University Initial Collection

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