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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5228

Title: Gastric Anti-Ulcer and cytoprotective effects of Cyamopsis Tetragonoloba (Guar) in rats
Authors: Rafatullah, S.
Al-Yahaya, M.A.
Al-Said, M.S.
Taragan, K.U. Abdul Hameed
Mossa, J.S.
Keywords: Gastric
Issue Date: 1994
Publisher: Swets & Zeitlinger
Citation: International Journal of Pharmacology: 32 ( 2); 163-170
Abstract: An ethanol extract of Cyamopsis tetragonoloba (Guar) has been studied for its ability to inhibit gastric secretion and to protect gastric mucosa against the injury caused by pylorus ligation, hypothermic restraint stress, indomethacin, and various necrotizing agents including 80% ethanol, 0.2 M NaOH and 2 5% NaCl in rats. An oral dose of 500 mg/kg of the extract produced inhibition of normal gastric secretion in rats. The extract inhibited acetylcholine-induced contractions of isolated guinea pig ileum, suggesting anti-cholinergic activity. The intensity of gastric lesions induced by hypothermic restraint stress and indomethacin was reduced significantly by Guar extract. It produced a marked cytoprotective effect against all the necrotizing agents used in this study. The extract not only increased the gastric wall mucus significantly but also restored the ethanol-induced depletion of nonprotein sulfhydryl (NP-SH) content in the glandular stomachs of rats.
Description: Medicinal, Aromatic and Poisonous Plants Research Center, and Dept. of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia Phone: 00966-1-467-7207 Email:srafatullah@yahoo.com, srafat@ksu.edu.sa
URI: http://hdl.handle.net/123456789/5228
ISSN: 0925-1618
Appears in Collections:College of Pharmacy

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