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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5282

Title: Hepatoprotective and safety evaluation studies on Sarsaparilla
Authors: Rafatullah, S.
Mossa, J.S.
Al-Yahya, M.A.
Ageel, A.M.
Keywords: Hepatoprotective
Evaluation Studies
Issue Date: 1991
Publisher: Swets & Zeitlinger
Citation: Internatioanl Journal of Pharmacognosy: 29 (4); 296-301
Abstract: The effect of the ethanol extract of sarsaparilla (Smilax regelii) has been studied on carbon tetrachloride (CCi4)-induced hepatocellular damage in rats. Pretreatment with an ethanol extract of sarsaparilla significantly inhibited CCI4-induced biochemical changes. Acute and chronic toxicity studies were also undertaken to determine the safety of prolonged use of sarsaparilla. Acute administration of sarsaparilla extract in the dose range of 0.5 to 3.0 g/kg did not produce any adverse effects or mortality in mice over a period of 24 hours. Animals treated with sarsaparilla extract (100 mg/kg/ day) for a period of 90 days in drinking water showed no symptoms of toxicity. There was no significant change in body weight and hematological parameters in the chronically treated animals as compared to the control group. These findings suggest that sarsaparilla, besides having hepatoprotective potential, has no untoward effects in rodents.
Description: Corresponding Author: Mr. M. Tariq Medicinal, Aromatic and Poisonous Plants Research Center and Departments of Pharmacognosy and Pharmacology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia
URI: http://hdl.handle.net/123456789/5282
ISSN: 0925-1618
Appears in Collections:College of Pharmacy

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