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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5401

Title: Sensitive assay for carvedilol in tablets and spiked human plasma using a flow-injection chemiluminometric method
Authors: Al Arfaj, Nawal
Abdine, Heba H.
SuItan, Maha A.
Keywords: Carvedilol
Chemiluminescencef
Flow injection
Tris
Ruthenium
Human
Tablets
Plasma
Issue Date: Jun-2007
Publisher: Master Publishing Group
Citation: International Journal of Biomedical Science: 3 (2); 132-137
Abstract: A simple and sensitive chemiluminometric method using flow injection (FI) is developed for the determination of carvedilol, based on the reaction of carvedilol with tris (2, 2'-bipyridyl) ruthenium (II), and KMnO 4 in sulfuric acid medium. Under the optimum conditions; the chemiluminescence (CL) intensity is a linear function of carvedilol concentration over the range of 0.04-1.0 Jig ml-1 (9.8 x 10-8 - 2.5 x 10' mol L -I) with a detection limit (S/N=3) of 0.025 Jlgml-1 (6.2 x 10-8 mol L -I). The relative standard deviation of the proposed method calculated from 10 replicate injections of 0.4 Jig ml-1 carvedilol is 0.95%. The sample throughput is 90 samples h-i. The method is applied successfully to the determination of carvedilol in tablets dosage form and spiked human plasma
URI: http://hdl.handle.net/123456789/5401
Appears in Collections:College of Applied Medical Sciences

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