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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5649

Title: Gastroprotective effects of 'Amla' Emblica officinalis on in vivo test models in rats
Authors: Al-Rehaily, A.J.
Al-Howiriny, T.A.
Al-Sohaibani, M.O.
Rafatullah, S.
Keywords: Amla
Emblica officinalis
Euphorbiaceae
Gastroprotection
Traditional Medicine
Gastric lesions
Nonprotein
Sulfhydryl
Issue Date: 2002
Publisher: Urban & Fischer Verlag
Citation: Phytomedicine: 9; 515-522
Abstract: An ethanol extract of 'Amla' Emblica officinalis Gaertn. was examined for its antisecretory and antiulcer activities employing different experimental models in rats, including pylorus ligation Shay rats, indomethacin, hypothermic restraint stress-induced gastric ulcer and necrotizing agents (80% ethanol, 0.2 M NaOH and 25% NaCl). Oral administration of Amla extract at doses 250 mg/kg and 500 mg/kg significantly inhibited the development of gastric lesions in all test models used. It also caused significant decrease of the pyloric-ligation induced basal gastric secretion, titratable acidity and gastric mucosal injury. Besides, Amla extract offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl concentration. Histopathological analyses are in good agreement with pharmacological and biochemical findings. The results indicate that Amla extract possesses antisecretory, antiulcer, and cytoprotective properties.
Description: Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. 2 College of Medicine, Department of Pathology, King Khalid University Hospital, Riyadh, Saudi Arabia. Tel.: +96614677258; Fax: +9661)4677245 Email:ajalreha@ksu.edu.sa
URI: http://hdl.handle.net/123456789/5649
Appears in Collections:College of Pharmacy

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