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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5665

Title: Gastroprotective activity of ginger Zingiber officinale Rose, in Albino rats
Authors: Al-Yahya, M.A.
Ageel, A.M.
Rafatullah, S.
Mossa, J.S.
Parmar, N.S.
Tariq, M.
Keywords: Activity
Gastroprotective
Ginger Zingiber
Officinale Rose
Albino
Rats
Issue Date: 1989
Publisher: Institute for Advanced Research in Asian Science and Medicine
Citation: American Journal of Chinese Medicine: 17 (1-2); 51-56
Abstract: The cytoprotective and gastric anti-ulcer studies of ginger have been carried out in albino rats. Cytodestruction was produced by 8 0% ethanol, 0 . 6M H C 1 , 0 . 2M NaOH and 2 5% NaCl. Whereas gastric ulcers were produced by ulcerogenic agents including indomethacin, aspirin and reserpine, beside hypothermic restraint stress and by pylorus ligated Shay rat technique. The results of this study demonstrate that the extract in the dose of 5 0 0 mg/kg orally exert highly significant cytoprotection against 8 0% ethanol, 0 . 6M HC1, 0 . 2M NaOH and 25% NaCl induced gastric lesions. The extract also prevented the occurrence of gastric ulcers induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and hypothermic restraint stress. These observations suggest cytoprotective and anti-ulcerogenic effect of the ginger.
Description: Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh-11451, Saudi Arabia Tel.: (+9661)4677262; Fax: +96614677245 Email: alyahya@ksu.edu.sa
URI: http://hdl.handle.net/123456789/5665
Appears in Collections:College of Pharmacy

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