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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5781

Title: Gastroprotective effect of radish “Raphanus Sativus” L. on experimental Gastric ulcer models in rats
Authors: Alqasoumi, Saleh
Al-Yahya, Mohammed
Al-Howiriny, Tawfeq
Rafatullah, Syed
Keywords: Gastroprotection
Gastric ulcer
Raphanus sativus L.
Experimental models
Brassicaceous plant
Gastric lesions
Issue Date: 2008
Citation: Farmacia: 56 (2); 204-214
Abstract: Raphanus sativus L. ‘Radish’ locally known as Fijl, is a Brassicaceous plant of cabbage family which has been reputed for its benefic medicinal properties. The present study was undertaken to evaluate the freshly squeezed Radish juice (FRJ) for its anti-gastric ulcer activity in experimental models, besides preliminary qualitative phytochemical screening. Oral administration of FRJ in doses of 2 and 4 ml/ 200 g b.w. significantly inhibited gastric ulcer formation induced by necrotizing agents (ethanol, sodium hydroxide and sodium chloride) hypothermic restraint-stress and indomethacin. The FRJ also replenished the ethanol induced depleted gastric wall mucus secretion and nonproteinsulfhydryl (NP-SH) concentrations in rats. The phytochemical screening showed the presence of flavonoids, anthocyanins and sulfurated constituents. In conclusion, the results indicate that the fresh juice of Radish possesses gastroprotective potential related to the mucus secretion stimulation (potentiation of defensive factors); and increase in NP-SH concentration is probably due to prostaglandin-inducing abilities, mediated through its antioxidant activity.
Description: Department of Pharmacognosy and Medicinal, Aromatic & Poisonous Plants Research Center (MAPPRC), College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia Email: srafat@ksu.edu.sa, srafatullah@yahoo.com
URI: http://hdl.handle.net/123456789/5781
Appears in Collections:College of Pharmacy

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