Gastroprotective effect of radish “Raphanus Sativus” L. on experimental Gastric ulcer models in rats

Abstract

Raphanus sativus L. ‘Radish’ locally known as Fijl, is a Brassicaceous plant of cabbage family which has been reputed for its benefic medicinal properties. The present study was undertaken to evaluate the freshly squeezed Radish juice (FRJ) for its anti-gastric ulcer activity in experimental models, besides preliminary qualitative phytochemical screening. Oral administration of FRJ in doses of 2 and 4 ml/ 200 g b.w. significantly inhibited gastric ulcer formation induced by necrotizing agents (ethanol, sodium hydroxide and sodium chloride) hypothermic restraint-stress and indomethacin. The FRJ also replenished the ethanol induced depleted gastric wall mucus secretion and nonproteinsulfhydryl (NP-SH) concentrations in rats. The phytochemical screening showed the presence of flavonoids, anthocyanins and sulfurated constituents. In conclusion, the results indicate that the fresh juice of Radish possesses gastroprotective potential related to the mucus secretion stimulation (potentiation of defensive factors); and increase in NP-SH concentration is probably due to prostaglandin-inducing abilities, mediated through its antioxidant activity.