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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/6275

Title: Effects of indomethacin of darns and foetuses of C57 BL/6J Mice
Authors: Abu-Tarbosh, F.M.
Keywords: Indomethacin
Issue Date: 1995
Publisher: King Saud University
Citation: Journal of King Saud University, Science: 7(1); 71-76
Abstract: Normal adult inbred C57 BL/6J mice were used to investigate the teratogenic and other possi-ble toxic effects of indomethacin on both dams and their foetuses. The dams have been treated with vari-ous doses of the drug once each day from day 7 to day 12 of pregnancy. The prenatal administration of the drug at 2, 3, 4 or 6 mg/kg body weight has significantly increased foetal mortality rate and decreased the mean number of live foetuses. The highest dose used (6 mg/kg body weight) has also significantly decreased the live foetal body weight. None of the doses used has induced any foetal malformations but the highest doses of the drug (4 and 6 mg/kg body weight) used were toxic on the dams.
URI: http://hdl.handle.net/123456789/6275
Appears in Collections:Journal of the King Saud University - Science

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