Regeneration of bifurcation in beagle dogs: histologic evaluation of two regeneration materials

Abstract

The aim of this study was to compare Emdogain and Guidor resorbable materials in the regeneration and/or healing of experimental Class II furcation lesions. Class II premolar furcation defects 3-5 mm high and 2.5-5 mm deep were experimentally induced in four beagle dogs. Dogs 1 and 2were assigned to one-stage surgery where the defect created was immediately followed by the placement of either Guidor or Emdogain or nothing (control). Dogs 2 and 4 were assigned to a two-stage approach where the creation of the defect was followed one month later with the membrane placement or nothing (control). After six months of healing animals were sacrificed. Subsequently, decalcified sections were prepared from all animals and used for histological evaluation. Accelular cementum was not a constant finding with the use of Emdogain. It was concluded that the two-stage surgery approach is a more predictable experimental model for the healing of Class II furcation.