Effect of L-thyroxine on some blood parameters of laboratory mice

Abstract

The effect of intraperitoneal administration of low dose (1 p.g/g) and high dose (4 p.g/g) of thyroid hormone after 6,24,72 and 96h on serum proteins, uric acid, triglycerides, glucose and cholesterol in laboratory mice has been investigated. Thyroxine treatment ,resulted in a biphasic effect on total proteins; lower dose induced anabolic effect while the higher was found to be catabolic. There was an initial decrease in uric acid concentration followed by a significant increase at 24h post-injection. Serum trig-lycerides and cholesterol values were significantly decreased in the experimental groups. The effect on triglycerides was found to be dose dependent. Both doses ofT4 resulted in a significant decrease in serum glucose level that was directly proportional to the hormonal dosage. The results are discussed in the light of earlier reports on thyroid hormones and mammalian physiology.