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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/639

Title: Effect of L-thyroxine on some blood parameters of laboratory mice
Authors: Al-Kanhal, Mohamad A.
Chaudhry, M. Asghar
Keywords: L-thyroxine
Blood parameters
Laboratory mice
Serum proteins
Uric acid
Issue Date: 1994
Publisher: King Saud University
Citation: Journal of King Saud University, Science: 6 (2); 197-206
Abstract: The effect of intraperitoneal administration of low dose (1 p.g/g) and high dose (4 p.g/g) of thyroid hormone after 6,24,72 and 96h on serum proteins, uric acid, triglycerides, glucose and cholesterol in laboratory mice has been investigated. Thyroxine treatment ,resulted in a biphasic effect on total proteins; lower dose induced anabolic effect while the higher was found to be catabolic. There was an initial decrease in uric acid concentration followed by a significant increase at 24h post-injection. Serum trig-lycerides and cholesterol values were significantly decreased in the experimental groups. The effect on triglycerides was found to be dose dependent. Both doses ofT4 resulted in a significant decrease in serum glucose level that was directly proportional to the hormonal dosage. The results are discussed in the light of earlier reports on thyroid hormones and mammalian physiology.
URI: http://hdl.handle.net/123456789/639
Appears in Collections:Journal of the King Saud University - Science

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