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Title: The effects of walterinnesia aegyptia venom on the serum and tissue metabolites and on some enzyme activities in albino rats. III-effect on lipid metabolism and two dehydrogenases
Authors: Al-Jammaz, I.
Al-Sadoon, M.K.
Fahim, A.
Attia, M.A.
Keywords: Walterinnesia aegyptia
Tissue metabolites
Enzyme activities
Albino rats
Lipid metabolism
Issue Date: 1994
Publisher: King Saud University
Citation: Journal of King Saud University, Science: 6(2); 207-215
Abstract: An LD 50 (0.2 mglkg) dose of Walterinnesia aegyptia venom to albino rats causes a significant decrease in total serum lipids, triacylglycerols and total cholseterol, with a decline in both glucose-6-phosphate dehydrogenase (G6PDH) and lactate dehydrogenase (LDH) activities, possibly due to lipolytic and specific inhibitors present in the venom. Accumulation of totallipids was observed in the liver, kidneys, heart and brain of envenomated animals with a subsequent insignificant decrease in total cholesterol and triacylglycerols, except in the liver, where the decrease was significant. This suggests mobilization of lipids from peripheral tissues to these organs accompanied by release of other components of totallipids such as phospholipids and fatty acids. Deficiency in the pentose phosphate pathway (PPP) , disturbance in the oxidoreduction system and altered energy metabolism were also detected. Variations in enzyme activities were also seen with the G6PDH level which generally elevated in the all organs studied, except in brain. The level of LDH declined in liver and kidney, but increased in heart and brain. This may suggest prevalence of anaerobic conditions in such organs as a result of venom detoxication.
URI: http://hdl.handle.net/123456789/640
Appears in Collections:Journal of the King Saud University - Science

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