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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/6499

Title: Protection by 2-Deoxy-D-glucose against b,b8-Iminodipropionitrile-Induced Neurobehavioral Toxicity in Mice
Authors: Tariq, Mohammad
Khan, Haseeb Ahmad
Moutaery, Khalaf Al
Deeb, Saleh Al
Keywords: Protection by 2-Deoxy-D-glucose
Iminodipropionitrile-Induced Neurobehavioral
Toxicity
IDPN-induced syndrome
Nonmetabolizable glucose
Mice
2-Deoxy-D-glucose
Issue Date: 26-Mar-1999
Publisher: Academic press
Citation: Experimental Neurology: 158; 229–233
Abstract: This investigation was undertaken to study the effect of 2-deoxy-D-glucose (2-DG) on b,b8-iminodipropionitrile (IDPN)-induced neurobehavioral toxicity in mice. Animals were divided into five groups of nine animals each. One of the groups served as control and received vehicle only, whereas the remaining four groups were treated with IDPN (250 mg/kg, ip) daily for 11 days. 2-DG was injected intraperitoneally in the doses of 0 (vehicle only), 100, 300, and 600 mg/kg daily 30 min before IDPN administration. The animals were observed for dyskinetic behavior including vertical (retrocollis) and horizontal (laterocollis) head movements and circling. Twenty-four hours after the last dose of IDPN, the animals were sacrificed by decapitation and striata were isolated from the brain for the analysis of serotonin (5-HT). Our results showed that 2-DG significantly and dose dependently attenuated the incidence and severity of IDPN-induced neurobehavioral toxicity. Administration of 2-DG also protected mice against IDPN-induced increase in striatal 5-HT levels. Further studies are warranted to investigate the neuroprotective mechanism of 2-DG against IDPN-induced neurotoxicity
URI: http://hdl.handle.net/123456789/6499
Appears in Collections:College of Science

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