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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/6516

Title: Protective effects of nedocromil sodium and sodium cromoglycate on gastroduodenal ulcers: a comparative study in rats
Authors: Mohammad Tariq
Al Moutaery, Meshal
Elfaki, Ibrahim
Arshaduddin, Mohammad
Khan, Haseeb Ahmad
Keywords: Gastric ulcers
Duodenal ulcers
Mast cells
Nedocromil
Cromoglycate
Issue Date: 2006
Publisher: Birkhäuser Verlag
Citation: Inflammopharmacology: 14; 169–175
Abstract: Stabilization of mast cells plays a key mechanism to protect gastrointestinal tract from injury. This study presents a comparative evaluation of mast cell stabilizers nedocromil sodium (NDS) and sodium cromoglycate (SCG) in experimental gastric and duodenal ulcers in rats. Wistar rats of either sex were used in this study. Both NDS and SCG, in the doses of 10, 30 and 100 mg/kg were given intraperitoneally for gastric secretion studies and by gavage for antiulcer studies. Acid secretion studies were undertaken in pylorus-ligated rats. Gastric lesions were induced by water immersion restraint stress (WIRS), indomethacin and ethanol whereas duodenal ulcers were produced by cysteamine. The level of glutathione (GSH) and gastric wall mucus were measured in glandular stomach of rats following ethanol-induced gastric lesions.
URI: http://hdl.handle.net/123456789/6516
ISSN: 0925-4692
Appears in Collections:College of Science

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