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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/6662

Title: Inhibition of gastric mucosal damage by methylglyoxal pretreatment in rats
Authors: Al-Shabanah, O.A.
Qureshi, S.
Al-Harbi, M.M.
Al-Bekairi, A.M.
Al-Gharably, N.M.
Raza, M.
Keywords: Methylglyoxal
Ulceration
Gastric--Secretions
Lipid--Peroxides
Glutathione
Medical Sciences
Issue Date: 2000
Publisher: Elsevier Science Ltd.
Citation: Food and Chemical Toxicology: 38; 577-584
Abstract: The effect of methylglyoxal pretreatment on gastric mucosal injuries caused by 80% ethanol, 25% NaCl and 0.2 m NaOH, was investigated in rats. The effects caused by pylorous ligation accumulated gastric acid secretions and ethanol-induced changes in gastric mucus secretions, levels of proteins, nucleic acid, malondialdehyde (MDA) and non-protein sulfhydryl groups were also investigated. Methylglyoxal pretreatment at oral doses of 50, 100 and 200 mg/kg body weight was found to provide a dose-dependent protection against the ulcerogenic effects of different necrotizing agents used. With the same dose regimen methyl-glyoxal offered significant protection against ethanol-induced damage on the parameters evaluated for histopathology. Furthermore, the pretreatment afforded a dose-dependent inhibition of pylorous ligated accumulation of gastric acid secretions and ethanol-induced depletion of stomach wall mucus, proteins, nucleic acids, NP-SH contents and an increase in the MDA levels in gastric tissue. The protective effect of methylglyoxal against ethanol-induced damage to the gastric wall mucosa may be mediated through its effect on mucous production, proteins, nucleic acids, NP-SH groups and its free-radical scavenging property under the in¯uence of polyamines stimulated by ornithine decarboxylase activity (ODC).
URI: http://hdl.handle.net/123456789/6662
ISSN: 0278-6915
Appears in Collections:College of Pharmacy

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