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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/7666

Title: Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice
Authors: Al-Shabanah, Othman A.
Alam, Khurshid
Nagi, Mahmoud N.
Al-Rikabi, Ammar C.
Al-Bekairi, Abdullah M.
Keywords: Aminoguanidine
Nitric oxide
Carbon Tetrachloride
Hepatotoxiciry
Issue Date: 1999
Publisher: Elsevier Science
Citation: Life Sciences: 66 (3); 265-270
Abstract: The present study was undertaken to evaluate the effect of aminoguanidine (AG) on carbon tetrachloride (CCU)-induced hepatotoxicity. Treatment of mice with CCU (20 pl/kg, i.p.) resulted in damage to centrilobular regions of the liver, increase in serum aminotransferase and rise in lipid peroxides level 24 hours after CCU administration. Pretreatment of mice with AG (50 mg/kg, i.p.) 30 minutes before CCU was found to protect mice from the CCU-induced hepatic toxicity. This protection was evident from the significant reduction in serum aminotransferase, inhibition of lipid peroxidation and prevention of CCU-induced hepatic necrosis revealed by histopathology. Aminoguanidine, a relatively specific inhibitor of inducible nitric oxide synthase, did not inhibit the in vitro lipid peroxidation. Taken together, these data suggest a potential role of nitric oxide as an important mediator of CCU-induced hepatotoxicity.
URI: http://hdl.handle.net/123456789/7666
ISSN: 0024-3205/00
Appears in Collections:College of Pharmacy

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