Synthesis and biological testing of new 1-adamantyl derivatives

Abstract

Several adamantane derivatives have long been known for their diverse biological properties, mainly as antiviral, antibacterial, antifungal and anti-inflammatory agents. Adamantyl derivatives were recently reported to possess 11b-HSD1 inhibitory activities. In addition, 1,2,4-triazole and 1,3,4-thiadiazole were reported to constitute the pharmacologically active moiety of several compounds. On these bases, new series of 1-adamantyl derivatives, in which the adamantyl moiety was attached to 1,2,4-triazole, 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole or 1,3,4- thiadiazole nucleus, have been synthesized as potential bioactive agents.