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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/9018

Title: Superovulation in cattle usingPMSG followed by PMSGmonoclonal antibodies
Authors: M.M. Alfuraiji
J.S.M. Hutchinsonv
P.J. Broadbent"
Issue Date: 1993
Abstract: The advantages of using pregnant mares' serum gonadotrophin (PMSG) to stimulate increased preovulatory follicular development are that it is available in large quantities at low cost, and can be administered as a single dose because of its long half-life. The long half-life, however, can have dis¬advantages since it may cause over and/or prolonged stimulation, leading to a second wave offollic¬ular development after ovulation and a secondary rise in oestradiol-l 7 p. The latter may interfere with embryo quality. PMSG antiserum I has been extensively tested in an effort to selectively remove PMSG from the peripheral blood ofPMSG stimulated cattle after the initial phase of follicular stimulation but before the secondary post-ovulatory phase of stimulation. This neutralisation of PMSG with PMSG anti¬serum prevents the secondary development of ovarian follicles and the accompanying rise in oestra¬diol-17 p; however, the evidence regarding the effect on the number of usable embryos recovered is conflicting. The best results, in this respect, have been obtained when PMSG antiserum was admin¬istered 5-6 h after the preovulatory LH peak but this event is difficult to assess in practice. Adminis¬tration of PMSG antiserum at a fixed time in relation to the use of either PMSG or a synchronising injection of a prostaglandin analogue, or in relation to the onset of behavioural oestrus is unsatisfac¬tory because of the variability of the timing of the LH peak in relation to these events. It may, how¬ever, be possible to use the preovulatory peak of oestradiol-l 7 p as a marker for the administration of PMSG antiserum.
URI: http://hdl.handle.net/123456789/9018
Appears in Collections:College of Foods And Agricultural Science

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