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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/9739

Title: The effect of folic acid fortification on plasma folate status and total homocysteine concentrations in folate depletion / repletion rats model
Authors: Hala. M. Hussein
Hanaa A.El-Ghany
O. Abd-Allah
Issue Date: 2005
Abstract: The practice of food fortification with folic acid offers the potential the folate intake for the maintenance of optimal health, as well as the prevention of the diseases. The purpose of this article is to study the effect of fortification of B-vitamins (folic acid and vitamin B-12) on the reduction of hyperhomocysteinemia, an independent risk factor for heart disease in folate depleted rats. This study included forty two albino rats (western strain), 36 rats were undergone to protocol of folate depletion for six weeks and six rats were fed folate deplated diet supplemented with 200µg folic acid as a basal diet that represent as normal control. After the depletion period, the rats (30) were divided into five subgroups. One of them continued feeding on unfortified French-bread that represented as depleted control, while the remaining subgroups were fed fortified French-bread with variable doses of B-vitamins for six weeks. The repletion period was continued for 6 weeks. After that, blood samples were undertaken to investigate the biochemical parameters. Our analysts suggested that plasma homocysteine (Hy) may be the more sensitive indictor of folate status at extremely low levels of folate intake. Daily folic acid fortification appear to be the most effective of reducing T-Hy concentrations. We concluded that to the policy of food fortification with folic acid as a means of raising the folate status of the population, and in particular to the fortification of specific food which may target areas of the population where increased folate status is most needed.
URI: http://hdl.handle.net/123456789/9739
Appears in Collections:College of Foods And Agricultural Science

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